Pulmonary health effects of wintertime particulate matter from California and China following repeated exposure and cessation.

ABSTRACT: Epidemiological studies show strong associations between fine particulate matter (PM_2.5) air pollution and adverse pulmonary effects. In the present study, wintertime PM_2.5 samples were collected from three geographically similar regions-Sacramento, California, USA; Jinan, Shandong, China; and Taiyuan, Shanxi, China-and extracted to form PM_CA, PM_SD, and PM_SX, respectively, for comparison in a BALB/c mouse model. Each of four groups was oropharyngeally administered Milli-Q water vehicle control (50 μL) or one type of PM extract (20 μg/50 μL) five times over two weeks. Mice were necropsied on post-exposure days 1, 2, and 4 and examined using bronchoalveolar lavage (BAL), histopathology, and assessments of cytokine/chemokine mRNA and prot

SUBMITTER: Yuan W 

PROVIDER: S-EPMC8671358 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature