Longitudinal changes in network engagement during cognitive control in cocaine use disorder.

ABSTRACT:

Background

Cocaine use disorder (CUD) is characterized by poor cognitive control and has limited empirically supported treatment options. Furthermore, an understanding of brain mechanisms underlying CUD is at a relatively early stage. Thus, this study aimed to investigate longitudinal alterations in functional neural networks associated with cognitive control in cocaine use disorder (CUD).

Methods

Secondary analysis was performed on data from 44 individuals who participated in three randomized clinical trials for CUD and completed an fMRI Stroop task both at baseline and post-treatment. Independent component analysis (ICA) was performed to assess changes in functional network engagement and investigate associations with cocaine-use behaviors. Mixed linear models were perform

SUBMITTER: Morie KP 

PROVIDER: S-EPMC8671376 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature