Evidence from theta-burst stimulation that age-related de-differentiation of the hippocampal network is functional for episodic memory.

ABSTRACT: Episodic memory is supported by hippocampal interactions with a distributed network. Aging is associated with memory decline and network de-differentiation. However, the role of de-differentiation in memory decline has not been directly tested. We reasoned that hippocampal network-targeted stimulation could test these theories, as age-related changes in the network response to stimulation would indicate network reorganization, and corresponding changes in memory would suggest that this reorganization is functional. We compared effects of stimulation on fMRI connectivity and memory in younger versus older adults. Theta-burst network-targeted stimulation of left lateral parietal cortex selectively increased hippocampal network connectivity and modulated memory in younger adults. In contrast,

SUBMITTER: Hermiller MS 

PROVIDER: S-EPMC8671378 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature