Stability of healthy subgingival microbiome across space and time.

ABSTRACT: The subgingival microbiome is one of the most stable microbial ecosystems in the human body. Alterations in the subgingival microbiome have been associated with periodontal disease, but their variations over time and between different subgingival sites in periodontally healthy individuals have not been well described. We performed extensive, longitudinal sampling of the subgingival microbiome from five periodontally healthy individuals to define baseline spatial and temporal variations. A total of 251 subgingival samples from 5 subjects were collected over 6-12 months and deep sequenced. The overall microbial diversity and composition differed significantly between individuals. Within each individual, we observed considerable differences in microbiome composition between different subgingi

SUBMITTER: Tamashiro R 

PROVIDER: S-EPMC8671439 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature