TRAP1 inhibits MIC60 ubiquitination to mitigate the injury of cardiomyocytes and protect mitochondria in extracellular acidosis.
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ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC8671480 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
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TRAP1 inhibits MIC60 ubiquitination to mitigate the injury of cardiomyocytes and protect mitochondria in extracellular acidosis.
Zhang Lingxiao L Su Ning N Luo Yuanyuan Y Chen Siyin S Zhao Tongfeng T
Cell death discovery 20211214 1
Extracellular acidosis-induced mitochondrial damage of cardiomyocytes leads to cardiac dysfunction, but no detailed mechanism or efficient therapeutic target has been reported. Here we found that the protein levels of MIC60 were decreased in H9C2 cells and heart tissues in extracellular acidosis, which caused mitochondrial damage and cardiac dysfunction. Overexpression of MIC60 maintains H9C2 cells viability, increases ATP production and mitochondrial membrane potential, mitigates the disruption ...[more]
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