Cognitive profiling and proteomic analysis of the modafinil analogue S-CE-123 in experienced aged rats.

ABSTRACT: The lack of novel cognitive enhancer drugs in the clinic highlights the prediction problems of animal assays. The objective of the current study was to test a putative cognitive enhancer in a rodent cognitive test system with improved translational validity and clinical predictivity. Cognitive profiling was complemented with post mortem proteomic analysis. Twenty-seven male Lister Hooded rats (26 months old) having learned several cognitive tasks were subchronically treated with S-CE-123 (CE-123) in a randomized blind experiment. Rats were sacrificed after the last behavioural procedure and plasma and brains were collected. A label-free quantification approach was used to characterize proteomic changes in the synaptosomal fraction of the prefrontal cortex. CE-123 markedly enhanced motivati

SUBMITTER: Gyertyan I 

PROVIDER: S-EPMC8671572 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature