Genetic epidemiology of autoinflammatory disease variants in Indian population from 1029 whole genomes.

ABSTRACT:

Background

Autoinflammatory disorders are the group of inherited inflammatory disorders caused due to the genetic defect in the genes that regulates innate immune systems. These have been clinically characterized based on the duration and occurrence of unprovoked fever, skin rash, and patient's ancestry. There are several autoinflammatory disorders that are found to be prevalent in a specific population and whose disease genetic epidemiology within the population has been well understood. However, India has a limited number of genetic studies reported for autoinflammatory disorders till date. The whole genome sequencing and analysis of 1029 Indian individuals performed under the IndiGen project persuaded us to perform the genetic epidemiology of the autoinflammatory disorders in In

SUBMITTER: Jain A 

PROVIDER: S-EPMC8671593 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature