Altered Expression of Transfer-RNA-Derived Small RNAs in Human With Rheumatic Heart Disease.

ABSTRACT: Rheumatic heart disease (RHD) remains a severe public health problem in developing countries. Atrial fibrillation (AF) is a medical complication of RHD. Although the understanding of disease pathogenesis has advanced in recent years, the key questions need to be addressed. Transfer RNA-derived small RNAs (tsRNAs) are a novel type of short non-coding RNAs with potential regulatory functions in various physiological and pathological processes. The present study used tsRNAs sequencing to investigate the relationship between RHD and atrial fibrillation (AF). Three paired cardiac papillary muscles were taken from six rheumatic RHD patients with AF (3 cases) or without AF (3 cases) from January 2016 to January 2017 in Xiangya Hospital, Central South University. A total of 219 precisely matched t

SUBMITTER: Yang ZY 

PROVIDER: S-EPMC8671610 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature