Identification of CALU and PALLD as Potential Biomarkers Associated With Immune Infiltration in Heart Failure.

ABSTRACT: Background: Inflammatory activation and immune infiltration play important roles in the pathologic process of heart failure (HF). The current study is designed to investigate the immune infiltration and identify related biomarkers in heart failure patients due to ischemic cardiomyopathy. Methods: Expression data of HF due to ischemic cardiomyopathy (CM) samples and non-heart failure (NF) samples were downloaded from gene expression omnibus (GEO) database. Differentially expressed genes (DEGs) between CM and NF samples were identified. Single sample gene set enrichment analysis (ssGSEA) was performed to explore the landscape of immune infiltration. Weighted gene co-expression network analysis (WGCNA) was applied to screen the most relevant module associated with immune infiltr

SUBMITTER: Liu X 

PROVIDER: S-EPMC8671636 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature