Familial Breast Cancer: Disease Related Gene Mutations and Screening Strategies for Chinese Population.

ABSTRACT:

Background

About 5%-10% of the breast cancer cases have a hereditary background, and this subset is referred to as familial breast cancer (FBC). In this review, we summarize the susceptibility genes and genetic syndromes associated with FBC and discuss the FBC screening and high-risk patient consulting strategies for the Chinese population.

Methods

We searched the PubMed database for articles published between January 2000 and August 2021. Finally, 380 pieces of literature addressing the genes and genetic syndromes related to FBC were included and reviewed.

Results

We identified 16 FBC-related genes and divided them into three types (high-, medium-, and low-penetrance) of genes according to their relative risk ratios. In addition, six genetic syndromes were found to b

SUBMITTER: Shen L 

PROVIDER: S-EPMC8671637 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature