Natural history and patterns of treatment change in Parkinson's disease: A retrospective chart review.

ABSTRACT:

Background

Parkinson's disease (PD) management seeks to balance the benefits and harms of current medications and evolves as the disease progresses. The natural history of PD and associated patterns of treatment change were analyzed to identify unmet needs in treatment of PD symptoms.

Methods

Medical charts of patients from clinics across the US diagnosed on or before June 30th, 2014 were retrospectively reviewed. Index date was the first clinic visit, and the post-index period was through study end (June 30th, 2019). Outcomes included the frequency of therapy changes in the post-index period, reasons for therapy change, and adverse events (AE).

Results

Patients (n = 203) at index were receiving levodopa-peripheral dopa decarboxylase inhibitor (PDDI) monotherapy (47%)

SUBMITTER: Navaratnam P 

PROVIDER: S-EPMC8671728 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature