Deciphering the Irregular Risk of Stroke Increased by Obesity Classes: A Stratified Mendelian Randomization Study.

ABSTRACT:

Background

To investigate the relationship between different classes of obesity and stroke, we conducted a stratified Mendelian randomization (MR) study.

Methods

The body mass index (BMI) data of 263,407 Europeans with three classes of obesity (obesity class I, 30 kg/m² ≤ BMI < 35 kg/m²; obesity class II, 35 kg/m² ≤ BMI < 40 kg/m²; obesity class III, 40 kg/m² ≤ BMI) were extracted from the Genetic Investigation of ANthropometric Traits (GIANT) consortium. Summary-level data of stroke and its subtypes [ischemic stroke (IS) and intracerebral hemorrhage (ICH)] were obtained from the genome-wide association study (GWAS) meta-analysis, which was performed by the MEGASTROKE consortium. MR methods were used to identify the caus

SUBMITTER: Zou X 

PROVIDER: S-EPMC8671740 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature