Longitudinal changes in brain parenchyma due to mild traumatic brain injury during the first year after injury.

ABSTRACT: Chronic gray matter (GM) atrophy is a known consequence of moderate and severe traumatic brain injuries but has not been consistently shown in mild traumatic brain injury (mTBI). The aim of this study was to investigate the longitudinal effect of uncomplicated mTBI on the brain's GM and white matter (WM) from 6 weeks to 12 months after injury. Voxel-based-morphometry (VBM) was computed with the T1-weighted images of 48 uncomplicated mTBI patients and 37 orthopedic controls. Over the period from 6 weeks to 12 months, only patients who experienced uncomplicated mTBI, but not control participants, showed significant GM decrease predominantly in the right hemisphere along the GM-CSF border in lateral and medial portions of the sensorimotor cortex extending into the rolandic operculum, middle f

SUBMITTER: Muller AM 

PROVIDER: S-EPMC8671787 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature