Relationship between PPAR-γ gene polymorphisms and ischemic stroke risk: A meta-analysis.

ABSTRACT:

Background

Published researches have suggested some associations between PPAR-γ and ischemic stroke (IS) development. This meta-analysis was conducted to evaluate the association between PPAR-γ gene polymorphisms and IS risk.

Materials and methods

A systematic search was conducted in PubMed, Embase, Web of Science, China National Knowledge Infrastructure, and WanFang databases. The pooled association of odd ratios (ORs) and its 95% confidence interval (CI) was calculated to assess the IS risk of PPAR-γ rs1801282 C/G and rs3856806 C/T polymorphisms. Furthermore, the heterogeneity test, cumulative analyses, sensitivity analyses, and publication bias were conducted.

Result

Sixteen publications with 3786 cases and 5343 controls were identified. Overall findings indicated

SUBMITTER: Cheng F 

PROVIDER: S-EPMC8671800 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature