A bio-inductive collagen scaffold that supports human primary tendon-derived cell growth for rotator cuff repair.

ABSTRACT:

Background

Rotator Cuff (RC) tendon tearing is a common clinical problem and there is a high incidence of revision surgery due to re-tearing. In an effort to improve patient outcome and reduce surgical revision, scaffolds have been widely used for augmentation of RC repairs. However, little is known about how scaffolds support tendon stem cell growth or facilitate tendon regeneration. The purpose of this study is to evaluate the structural and biological properties of a bioactive collagen scaffold (BCS) with the potential to promote tendon repair. Additionally, we conducted a pilot clinical study to assess the safety and feasibility of using the BCS for repair of RC tears.

Methods

A series of physical, ultrastructural, molecular and in vitro tests determined the bioco

SUBMITTER: Chen P 

PROVIDER: S-EPMC8671806 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature