Controlled growth factor delivery system with osteogenic-angiogenic coupling effect for bone regeneration.

ABSTRACT:

Objective

Bone regeneration involves a coordinated cascade of events that are regulated by several cytokines and growth factors, among which bone morphogenic protein-2 (BMP-2), vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2) play important roles. In this study, we investigated the effects of dual release of the three growth factors on bone regeneration in femur defects.

Methods

A composite consisting of Gelatin microparticles loaded with VEGF/FGF-2 and poly(lactic-co-glycolic acid)-poly(ethylene glycol)-carboxyl (PLGA-PEG-COOH) microparticles loaded with BMP-2 encapsulated in a nano hydroxyapatite-poly actic-co-glycolic acid (nHA-PLGA) scaffold was prepared for the dual release of the growth factors.

Results

On the 14th day, decreased

SUBMITTER: Kang F 

PROVIDER: S-EPMC8671819 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature