Grey matter connectome abnormalities and age-related effects in antipsychotic-naive schizophrenia.

ABSTRACT:

Background

Convergent evidence is increasing to indicate progressive brain abnormalities in schizophrenia. Knowing the brain network features over the illness course in schizophrenia, independent of effects of antipsychotic medications, would extend our sight on this question.

Methods

We recruited 237 antipsychotic-naive patients with schizophrenia range from 16 to 73 years old, and 254 healthy controls. High-resolution T1 weighted images were obtained with a 3.0T MR scanner. Grey matter networks were constructed individually based on the similarities of regional grey matter measurements. Network metrics were compared between patient groups and healthy controls, and regression analyses with age were conducted to determine potential differential rate of age-related changes be

SUBMITTER: Yang B 

PROVIDER: S-EPMC8671864 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature