Sarcoidosis-like reaction after neoadjuvant pembrolizumab combined with chemotherapy mimicking disease progression of NSCLC induced encouraging discovery of pathological complete response.
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ABSTRACT:
SUBMITTER: Shi Y
PROVIDER: S-EPMC8671890 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
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Sarcoidosis-like reaction after neoadjuvant pembrolizumab combined with chemotherapy mimicking disease progression of NSCLC induced encouraging discovery of pathological complete response.
Shi Yuequan Y Li Ji J Chen Minjiang M Liu Hongsheng H Ma Dongjie D Lin Yuxiao Y Wang Mengzhao M Xu Yan Y
Thoracic cancer 20211111 24
Neoadjuvant chemoimmunotherapy has demonstrated improved efficacy and prognosis in stage IIa-IIIb patients with non-small cell lung cancer (NSCLC). Drug-induced sarcoidosis-like reaction (DISR), an autoimmune reaction, has been reported as a type of immune-related adverse event that may mimic disease progression. Here, we report the case of patient with NSCLC who developed DISR during neoadjuvant chemoimmunotherapy and finally achieved pathological complete response after surgery. ...[more]
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