Mesoporous Silica Nanoparticles Functionalized with Amino Groups for Biomedical Applications.

ABSTRACT: The synthesis and characterization of amino-functionalized mesoporous silica nanoparticles are presented following two different synthetic methods: co-condensation and post-synthesis grafting of 3-aminopropyltriethoxysilane. The amino groups' distribution on the mesoporous silica nanoparticles was evaluated considering the aggregation state of a grafted photosensitizer (Verteporfin) by using spectroscopic techniques. The homogeneous distribution of amino groups within the silica network is a key factor to avoid aggregation during further organic functionalization and to optimize the performance of functionalized silica nanoparticles in biomedical applications. In addition, the formation of a protein corona on the external surface of both bare and amino-functionalized mesoporous silica was

SUBMITTER: Estevao BM 

PROVIDER: S-EPMC8671895 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature