The promoter hypermethylation of SULT2B1 accelerates esophagus tumorigenesis via downregulated PER1.

ABSTRACT:

Background

Esophageal cancer is currently the eighth most common tumor in the world and a leading cause of cancer death. SULT2B1 plays crucial roles in tumorigenesis. The purpose of this study is to explore the role of SULT2B1 in esophageal squamous cell carcinoma (ESCC).

Methods

The expression of SULT2B1 and its clinicopathological characteristics were evaluated in ESCC cohorts. Bisulfite genomic sequencing and methylation specific PCR were used to detect the promoter hypermethylation of the SULT2B1 gene. The effects of SULT2B1 on the biological characters of ESCC cells were identified on functional assays. Subcutaneous xenograft models revealed the role of SULT2B1 in vivo with tumor growth. RNA-Seq analysis and qRT-PCR were performed to recognize the targeted effect of SUL

SUBMITTER: Li Z 

PROVIDER: S-EPMC8671905 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature