Genetic variants at the <i>RTP4/MASP1</i> locus are associated with fatigue in Scandinavian patients with primary Sjogren's syndrome.

ABSTRACT:

Objectives

Fatigue is common and severe in primary Sjögren's syndrome (pSS). The aim of this study was to identify genetic determinants of fatigue in pSS through a genome-wide association study.

Methods

Patients with pSS from Norway, Sweden, UK and USA with fatigue and genotype data available were included. After genotype imputation and quality control, 682 patients and 4 966 157 genetic markers were available. Association analysis in each cohort using linear regression with fatigue as a continuous variable and meta-analyses between the cohorts were performed.

Results

Meta-analysis of the Norwegian and Swedish cohorts identified five polymorphisms within the same linkage disequilibrium block at the receptor transporter protein 4 (RTP4)/MASP1 locus associated wi

SUBMITTER: Norheim KB 

PROVIDER: S-EPMC8671987 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature