The Human SCN10A^G1662S Point Mutation Established in Mice Impacts on Mechanical, Heat, and Cool Sensitivity.

ABSTRACT: The voltage-gated sodium channel NAV1.8 is expressed in primary nociceptive neurons and is involved in pain transmission. Mutations in the SCN10A gene (encoding NAV1.8 channel) have been identified in patients with idiopathic painful small fiber neuropathy (SFN) including the SCN10A^G1662S gain-of-function mutation. However, the role of this mutation in pain sensation remains unknown. We have generated the first mouse model for the G1662S mutation by using homologous recombination in embryonic stem cells. The corresponding Scn10a^G1663S mouse line has been analyzed for Scn10a expression, intraepidermal nerve fiber density (IENFD), and nociception using behavioral tests for thermal and mechanical sensitivity. The Scn10a^G1663S mutants had a similar Scn10a expre

SUBMITTER: Chidiac C 

PROVIDER: S-EPMC8671994 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature