Chlorhexidine oral rinses for symptomatic COPD: a randomised, blind, placebo-controlled preliminary study.

ABSTRACT:

Objectives

Determine the effect of twice-daily chlorhexidine oral rinses on oral and lung microbiota biomass and respiratory symptoms.

Setting

Single centre.

Participants

Participants were aged 40-85 with chronic obstructive pulmonary disease (COPD) and chronic productive cough or COPD exacerbation within the last year. Exclusions included antibiotics in the previous 2 months and/or those with less than four teeth. Forty-four participants were recruited and 40 completed the study.

Intervention

Participants were randomised 1:1 to twice-daily 0.12% chlorhexidine oral rinses versus placebo for 2 months along with daily diaries. St. George's Respiratory Questionnaire (SGRQ), blood tests, oral rinse and induced sputum were collected at randomisation and the final vi

SUBMITTER: Pragman AA 

PROVIDER: S-EPMC8672026 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature