Ontology highlight
ABSTRACT:
SUBMITTER: Venkat K
PROVIDER: S-EPMC8672173 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Venkat Kavyaa K Hoyos Mona M Haycocks James Rj JR Cassidy Liam L Engelmann Beatrice B Rolle-Kampczyk Ulrike U von Bergen Martin M Tholey Andreas A Grainger David C DC Papenfort Kai K
The EMBO journal 20211006 24
Bacterial small RNAs (sRNAs) are well known to modulate gene expression by base pairing with trans-encoded transcripts and are typically non-coding. However, several sRNAs have been reported to also contain an open reading frame and thus are considered dual-function RNAs. In this study, we discovered a dual-function RNA from Vibrio cholerae, called VcdRP, harboring a 29 amino acid small protein (VcdP), as well as a base-pairing sequence. Using a forward genetic screen, we identified VcdRP as a r ...[more]