Ontology highlight
ABSTRACT:
SUBMITTER: Xu Y
PROVIDER: S-EPMC8672174 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Xu Yingjiang Y Shi Ting T Cui Xuan X Yan Linyu L Wang Qi Q Xu Xiaoyan X Zhao Qingwen Q Xu Xiaoxuan X Tang Qi-Qun QQ Tang Huiru H Pan Dongning D
The EMBO journal 20211027 24
Brown and beige fat are specialized for energy expenditure by dissipating energy from glucose and fatty acid oxidation as heat. While glucose and fatty acid metabolism have been extensively studied in thermogenic adipose tissues, the involvement of amino acids in regulating adaptive thermogenesis remains little studied. Here, we report that asparagine supplementation in brown and beige adipocytes drastically upregulated the thermogenic transcriptional program and lipogenic gene expression, so th ...[more]