Robust Antigen-Specific T Cell Activation within Injectable 3D Synthetic Nanovaccine Depots.

ABSTRACT: Synthetic cancer vaccines may boost anticancer immune responses by co-delivering tumor antigens and adjuvants to dendritic cells (DCs). The accessibility of cancer vaccines to DCs and thereby the delivery efficiency of antigenic material greatly depends on the vaccine platform that is used. Three-dimensional scaffolds have been developed to deliver antigens and adjuvants locally in an immunostimulatory environment to DCs to enable sustained availability. However, current systems have little control over the release profiles of the cargo that is incorporated and are often characterized by an initial high-burst release. Here, an alternative system is designed that co-delivers antigens and adjuvants to DCs through cargo-loaded nanoparticles (NPs) incorporated within biomaterial-based scaffold

SUBMITTER: Weiden J 

PROVIDER: S-EPMC8672349 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature