Identification of key pathways and RNAs associated with skeletal muscle atrophy after spinal cord injury.

ABSTRACT:

Objective

This study was performed to investigate the potential key molecules involved in the progression of skeletal muscle atrophy after SCI.

Methods

Based on GSE21497 dataset, the DEmRNAs and DElncRNAs were screened after differentially expressed analysis. Then the enrichment analyses were performed on DEmRNAs. Then the PPI network and ceRNA network were constructed. Finally, the DGIdb was utilized to predict drug-gene interactions.

Results

A total of 412 DEmRNAs and 21 DElncRNAs were obtained. The DEmRNAs were significantly enriched in MAPK signaling pathway and FoxO signaling pathway. In addition, UBE2D1, JUN, and FBXO32 had higher node degrees in PPI network, and the top 20 genes with high degree were significantly enriched in FoxO signaling pathway and Endometr

SUBMITTER: Wei L 

PROVIDER: S-EPMC8672411 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature