Ageing and rejuvenation models reveal changes in key microbial communities associated with healthy ageing.

ABSTRACT:

Background

The gut microbiota is associated with diverse age-related disorders. Several rejuvenation methods, such as probiotic administration and faecal microbiota transplantation, have been applied to alter the gut microbiome and promote healthy ageing. Nevertheless, prolongation of the health span of aged mice by remodelling the gut microbiome remains challenging.

Results

Here, we report the changes in gut microbial communities and their functions in mouse models during ageing and three rejuvenation procedures including co-housing, serum-injection and parabiosis. Our results showed that the compositional structure and gene abundance of the intestinal microbiota changed dynamically during the ageing process. Through the three rejuvenation procedures, we observed that the m

SUBMITTER: Shin J 

PROVIDER: S-EPMC8672520 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature