Transcriptomics of single dose and repeated carbon black and ozone inhalation co-exposure highlight progressive pulmonary mitochondrial dysfunction.

ABSTRACT:

Background

Air pollution is a complex mixture of particles and gases, yet current regulations are based on single toxicant levels failing to consider potential interactive outcomes of co-exposures. We examined transcriptomic changes after inhalation co-exposure to a particulate and a gaseous component of air pollution and hypothesized that co-exposure would induce significantly greater impairments to mitochondrial bioenergetics. A whole-body inhalation exposure to ultrafine carbon black (CB), and ozone (O₃) was performed, and the impact of single and multiple exposures was studied at relevant deposition levels. C57BL/6 mice were exposed to CB (10 mg/m³) and/or O₃ (2 ppm) for 3 h (either a single exposure or four independent exposures). RNA was isola

SUBMITTER: Hathaway QA 

PROVIDER: S-EPMC8672524 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature