DE-STRESS: a user-friendly web application for the evaluation of protein designs.

ABSTRACT: De novo protein design is a rapidly growing field, and there are now many interesting and useful examples of designed proteins in the literature. However, most designs could be classed as failures when characterised in the lab, usually as a result of low expression, misfolding, aggregation or lack of function. This high attrition rate makes protein design unreliable and costly. It is possible that some of these failures could be caught earlier in the design process if it were quick and easy to generate information and a set of high-quality metrics regarding designs, which could be used to make reproducible and data-driven decisions about which designs to characterise experimentally. We present DE-STRESS (DEsigned STRucture Evaluation ServiceS), a web application for evaluating structural m

SUBMITTER: Stam MJ 

PROVIDER: S-EPMC8672653 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature