Obsessive-Compulsive Disorder Interactome Profile Analysis: A Perspective From Molecular Mechanism.

ABSTRACT:

Introduction

Obsessive-Compulsive Disorder (OCD) is one of the complex neuropsychiatric conditions. This disorder disables individuals in many different aspects of their personal and social life. Interactome analysis may provide a better understanding of this disorder's molecular origin and its underlying mechanisms.

Methods

In this study, the OCD-associated genes were extracted from the literature. The criterion for gene selection was to choose genes with at least one significant report. Furthermore, by applying Cytoscape and its plugins, protein-protein interaction network, and gene ontology of the 31 candidate genes related to OCD from genetic association studies is examined. The cross-validation method was used for network centrality assessment.

Results

A scale-fr

SUBMITTER: Zamanian-Azodi M 

PROVIDER: S-EPMC8672674 | biostudies-literature | 2021 Mar-Apr

REPOSITORIES: biostudies-literature