Sphingosine-1-phosphate receptor 1 agonist SEW2871 alters membrane properties of late-firing somatostatin expressing neurons in the central lateral amygdala.

ABSTRACT: Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that mediates a wide spectrum of biological processes including apoptosis, immune response and inflammation. Here, we sought to understand how S1P signaling affects neuronal excitability in the central amygdala (CeA), which is a brain region associated with fear learning, aversive memory, and the affective dimension of pain. Because the G-protein coupled S1P receptor 1 (S1PR₁) has been shown to be the primary mediator of S1P signaling, we utilized S1PR₁ agonist SEW2871 and S1PR₁ antagonist NIBR to determine a potential role of S1PR₁ in altering the cellular physiology of neurons in the lateral division of the CeA (CeL) that share the neuronal lineage marker somatostatin (Sst). CeL-Sst neur

SUBMITTER: Mork BE 

PROVIDER: S-EPMC8672675 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature