Dataset Information

Minimally Invasive Tissue Sampling: A Tool to Guide Efforts to Reduce AIDS-Related Mortality in Resource-Limited Settings.

ABSTRACT:

Background

Available information on the causes of death among people living with human immunodeficiency virus (PLHIV) in low- and middle-income countries (LMICs) remains scarce. We aimed to provide data on causes of death in PLHIV from two LMICs, Brazil and Mozambique, to assess the impact of clinical misdiagnosis on mortality rates and to evaluate the accuracy of minimally invasive tissue sampling (MITS) in determining the cause of death in PLHIV.

Methods

We performed coupled MITS and complete autopsy on 164 deceased PLHIV (18 children, 36 maternal deaths, and 110 adults). HIV antibody levels and HIV RNA viral loads were determined from postmortem serum samples.

Results

Tuberculosis (22.7%), toxoplasmosis (13.9%), bacterial infections (13.9%), and cryptococcosis (10.9%) were the leading causes of death in adults. In maternal deaths, tuberculosis (13.9%), bacterial infections (13.9%), cryptococcosis (11.1%), and cerebral malaria (8.3%) were the most frequent infections, whereas viral infections, particularly cytomegalovirus (38.9%), bacterial infections (27.8%), pneumocystosis (11.1%), and HIV-associated malignant neoplasms (11.1%) were the leading cause among children. Agreement between the MITS and the complete autopsy was 100% in children, 91% in adults, and 78% in maternal deaths. The MITS correctly identified the microorganism causing death in 89% of cases.

Conclusions

Postmortem studies provide highly granular data on the causes of death in PLHIV. The inaccuracy of clinical diagnosis may play a significant role in the high mortality rates observed among PLHIV in LMICs. MITS might be helpful in monitoring the causes of death in PLHIV and in highlighting the gaps in the management of the infections.

SUBMITTER: Letang E

PROVIDER: S-EPMC8672756 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Publications

Minimally Invasive Tissue Sampling: A Tool to Guide Efforts to Reduce AIDS-Related Mortality in Resource-Limited Settings.

Letang Emilio E Rakislova Natalia N Martinez Miguel J MJ Carlos Hurtado Juan J Carrilho Carla C Bene Rosa R Mandomando Inacio I Quintó Llorenç L Nhampossa Tacilta T Chicamba Valéria V Luis Elvira E Ismail Mamudo R MR Fernandes Fabiola F Lorenzoni Cesaltina C Ferreira Luiz L Freire Monique M Teresa Rodrigo-Calvo Maria M Guerrero José J Munguambe Khátia K Maixenchs Maria M Navarro Mireia M Casas Isaac I Marimon Lorena L Ferrando Melania M Macete Eusebio E Lacerda Marcus M Bassat Quique Q Menéndez Clara C Ordi Jaume J

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20211201 Suppl_5

<h4>Background</h4>Available information on the causes of death among people living with human immunodeficiency virus (PLHIV) in low- and middle-income countries (LMICs) remains scarce. We aimed to provide data on causes of death in PLHIV from two LMICs, Brazil and Mozambique, to assess the impact of clinical misdiagnosis on mortality rates and to evaluate the accuracy of minimally invasive tissue sampling (MITS) in determining the cause of death in PLHIV.<h4>Methods</h4>We performed coupled MIT ...[more]

PMID: 34910173

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Dataset Information

Minimally Invasive Tissue Sampling: A Tool to Guide Efforts to Reduce AIDS-Related Mortality in Resource-Limited Settings.

Background

Methods

Results

Conclusions

Publications

Minimally Invasive Tissue Sampling: A Tool to Guide Efforts to Reduce AIDS-Related Mortality in Resource-Limited Settings.

Similar Datasets

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