The Effect of Diabetes and Prediabetes on Mycobacterium tuberculosis Transmission to Close Contacts.

ABSTRACT:

Background

It is unknown whether dysglycemia is associated with Mycobacterium tuberculosis transmission.

Methods

We assessed epidemiological and clinical characteristics of patients with culture-confirmed pulmonary tuberculosis and their close contacts, enrolled in a multicenter prospective cohort in Brazil. Contacts were investigated at baseline and 6 months after enrollment. QuantiFERON positivity at baseline and conversion (from negative to positive at month 6) were compared between subgroups of contacts according to glycemic status of persons with tuberculosis (PWTB) as diabetes mellitus (DM) or prediabetes. Multivariable mixed-effects logistic regression models were performed to test independent associations with baseline QuantiFERON positive and QuantiFERON conversion.

SUBMITTER: Arriaga MB 

PROVIDER: S-EPMC8672762 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature