Durability of SARS-CoV-2-Specific T-Cell Responses at 12 Months Postinfection.

ABSTRACT:

Background

Characterizing the longevity and quality of cellular immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enhances understanding of coronavirus disease 2019 (COVID-19) immunity that influences clinical outcomes. Prior studies suggest SARS-CoV-2-specific T cells are present in peripheral blood 10 months after infection. Analysis of the function, durability, and diversity of cellular response long after natural infection, over a range of ages and disease phenotypes, is needed to identify preventative and therapeutic interventions.

Methods

We identified participants in our multisite longitudinal, prospective cohort study 12 months after SARS-CoV-2 infection representing a range of disease severity. We investigated function, phenotypes, and

SUBMITTER: Lu Z 

PROVIDER: S-EPMC8672777 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature