Selective oxidative stress induces dual damage to telomeres and mitochondria in human T cells.

ABSTRACT: Oxidative stress caused by excess reactive oxygen species (ROS) accelerates telomere erosion and mitochondrial injury, leading to impaired cellular functions and cell death. Whether oxidative stress-mediated telomere erosion induces mitochondrial injury, or vice versa, in human T cells-the major effectors of host adaptive immunity against infection and malignancy-is poorly understood due to the pleiotropic effects of ROS. Here we employed a novel chemoptogenetic tool that selectively produces a single oxygen (¹ O₂ ) only at telomeres or mitochondria in Jurkat T cells. We found that targeted ¹ O₂ production at telomeres triggered not only telomeric DNA damage but also mitochondrial dysfunction, resulting in T cell apoptotic death. Conversely, targ

SUBMITTER: Wang L 

PROVIDER: S-EPMC8672791 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature