Proliferation Cycle Transcriptomic Signatures are Strongly associated With Gastric Cancer Patient Survival.

ABSTRACT: Gastric cancer is one of the most heterogeneous tumors with multi-level molecular disturbances. Sustaining proliferative signaling and evading growth suppressors are two important hallmarks that enable the cancer cells to become tumorigenic and ultimately malignant, which enable tumor growth. Discovering and understanding the difference in tumor proliferation cycle phenotypes can be used to better classify tumors, and provide classification schemes for disease diagnosis and treatment options, which are more in line with the requirements of today's precision medicine. We collected 691 eligible samples from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database, combined with transcriptome data, to explore different heterogeneous proliferation cycle phenotypes, and further

SUBMITTER: Hu J 

PROVIDER: S-EPMC8672820 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature