Investigating 3,3-diaryloxetanes as potential bioisosteres through matched molecular pair analysis.

ABSTRACT: Oxetanes have received increasing interest in medicinal chemistry as attractive polar and low molecular weight motifs. The application of oxetanes as replacements for methylene, methyl, gem-dimethyl and carbonyl groups has been demonstrated to often improve chemical properties of target molecules for drug discovery purposes. The investigation of the properties of 3,3-diaryloxetanes, particularly of interest as a benzophenone replacement, remains largely unexplored. With recent synthetic advances in accessing this motif we studied the effects of 3,3-diaryloxetanes on the physicochemical properties of 'drug-like' molecules. Here, we describe our efforts in the design and synthesis of a range of drug-like compounds for matched molecular pair analysis to investigate the viability of the

SUBMITTER: Dubois MAJ 

PROVIDER: S-EPMC8672821 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature