Cognitive impairment and the regional distribution of cerebellar lesions in multiple sclerosis.

ABSTRACT:

Background

Cerebellar lesions are often reported in relapsing-remitting multiple sclerosis (RRMS) and have been associated with impaired motor function and cognitive status. However, prior research has primarily focused on summary measures of cerebellar involvement (e.g. total lesion load, gray/white matter volume) and not on the effect of lesion load within specific regions of cerebellar white matter.

Objective

Spatially map the probability of cerebellar white matter lesion (CWML) occurrence in RRMS and explore the relationship between cognitive impairment and lesion (CWML) location within the cerebellum.

Methods

High-resolution structural magnetic resonance imaging (MRI) was acquired on 16 cognitively impaired (CI) and 15 cognitively preserved (CP) RRMS subjects at

SUBMITTER: Tobyne SM 

PROVIDER: S-EPMC8673326 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature