A Multi-Omic Huntington's Disease Transgenic Sheep-Model Database for Investigating Disease Pathogenesis.

ABSTRACT:

Background

The pathological mechanism of cellular dysfunction and death in Huntington's disease (HD) is not well defined. Our transgenic HD sheep model (OVT73) was generated to investigate these mechanisms and for therapeutic testing. One particular cohort of animals has undergone focused investigation resulting in a large interrelated multi-omic dataset, with statistically significant changes observed comparing OVT73 and control 'omic' profiles and reported in literature.

Objective

Here we make this dataset publicly available for the advancement of HD pathogenic mechanism discovery.

Methods

To enable investigation in a user-friendly format, we integrated seven multi-omic datasets from a cohort of 5-year-old OVT73 (n = 6) and control (n = 6) sheep into a single databa

SUBMITTER: Mears ER 

PROVIDER: S-EPMC8673501 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature