Associations Between Brain Volumes and Cognitive Tests with Hypertensive Burden in UK Biobank.

ABSTRACT:

Background

Mid-life hypertension is an established risk factor for cognitive impairment and dementia and related to greater brain atrophy and poorer cognitive performance. Previous studies often have small sample sizes from older populations that lack utilizing multiple measures to define hypertension such as blood pressure, self-report information, and medication use; furthermore, the impact of the duration of hypertension is less extensively studied.

Objective

To investigate the relationship between hypertension defined using multiple measures and length of hypertension with brain measure and cognition.

Methods

Using participants from the UK Biobank MRI visit with blood pressure measurements (n = 31,513), we examined the cross-sectional relationships between hyperte

SUBMITTER: Newby D 

PROVIDER: S-EPMC8673518 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature