Expression of human HIPKs in Drosophila demonstrates their shared and unique functions in a developmental model.

ABSTRACT: Homeodomain-interacting protein kinases (HIPKs) are a family of four conserved proteins essential for vertebrate development, as demonstrated by defects in the eye, brain, and skeleton that culminate in embryonic lethality when multiple HIPKs are lost in mice. While HIPKs are essential for development, functional redundancy between the four vertebrate HIPK paralogues has made it difficult to compare their respective functions. Because understanding the unique and shared functions of these essential proteins could directly benefit the fields of biology and medicine, we addressed the gap in knowledge of the four vertebrate HIPK paralogues by studying them in the fruit fly Drosophila melanogaster, where reduced genetic redundancy simplifies our functional assessment. The single hipk present i

SUBMITTER: Kinsey SD 

PROVIDER: S-EPMC8673556 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature