Negative Transpulmonary Pressure Disrupts Airway Morphogenesis by Suppressing Fgf10.

ABSTRACT: Mechanical forces are increasingly recognized as important determinants of cell and tissue phenotype and also appear to play a critical role in organ development. During the fetal stages of lung morphogenesis, the pressure of the fluid within the lumen of the airways is higher than that within the chest cavity, resulting in a positive transpulmonary pressure. Several congenital defects decrease or reverse transpulmonary pressure across the developing airways and are associated with a reduced number of branches and a correspondingly underdeveloped lung that is insufficient for gas exchange after birth. The small size of the early pseudoglandular stage lung and its relative inaccessibility in utero have precluded experimental investigation of the effects of transpulmonary pressure on

SUBMITTER: Stanton AE 

PROVIDER: S-EPMC8673560 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature