Hypercoagulation detected by routine and global laboratory hemostasis assays in patients with infective endocarditis.

ABSTRACT:

Background

Coagulation system is heavily involved into the process of infective endocarditis (IE) vegetation formation and can facilitate further embolization. In this study we aimed to assess the coagulation and platelet state in IE implementing a wide range of standard and global laboratory assays. We also aim to determine whether prothrombotic genetic polymorphisms play any role in embolization and mortality in IE patients.

Methods

37 patients with IE were enrolled into the study. Coagulation was assessed using standard coagulation assays (activated partial thromboplastin time (APTT), prothrombin, fibrinogen, D-dimer concentrations) and integral assays (thromboelastography (TEG) and thrombodynamics (TD)). Platelet functional activity was estimated by flow cytometry. Singl

SUBMITTER: Koltsova EM 

PROVIDER: S-EPMC8673624 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature