The immunomodulatory effect of microglia on ECM neuroinflammation via the PD-1/PD-L1 pathway.

ABSTRACT:

Introduction

The experimental cerebral malaria (ECM) model in C57BL/6 mice infected with Plasmodium berghei ANKA (PbA) has revealed microglia are involved in the ECM immune microenvironment. However, the regulation of microglia in the ECM immune response is not clear, and there is no safe and efficient treatment clinically for the protection of the nerve cells.

Aims

To elucidate the negative regulation mechanism in the ECM brain mediated by microglia. Furthermore, to investigate protective effect of the appropriate enhancement of the PD-1/PD-L1 pathway in the brain against ECM through the intrathecal injection of the adenovirus expressing PDL1-IgG1Fc fusion protein.

Results

The PD-1/PD-L1 pathway was induced in the ECM brain and showed an upregulation in the microglia

SUBMITTER: Shen Y 

PROVIDER: S-EPMC8673706 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature