Alterations in the gut microbiome with hemorrhagic transformation in experimental stroke.

ABSTRACT:

Objective

Hemorrhagic transformation (HT) is a life-threatening complication of stroke. Whether changes in gut microbial composition underlie the development of HT remains unknown. This study aimed to investigate whether the gut microbiota is altered in HT rats and examine the association between these changes and inflammatory responses.

Methods

HT was successfully established in rats injected with 50% glucose (6 ml/Kg, i.p.) 15 min before middle cerebral artery occlusion (MCAO, 90 min occlusion) with reperfusion. After 5 days, rats were euthanized, and their brains used to estimate infarct volume. The inflammatory factors, the analysis of gut microbiota, and short-chain fatty acids (SCFA) were assessed.

Results

In contrast with non-HT rats, gut microbiota sequencing

SUBMITTER: Huang Q 

PROVIDER: S-EPMC8673707 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature