Effect of deep brain stimulation on brain network and white matter integrity in Parkinson's disease.

ABSTRACT:

Aims

The effects of subthalamic nucleus (STN)-deep brain stimulation (DBS) on brain topological metrics, functional connectivity (FC), and white matter integrity were studied in levodopa-treated Parkinson's disease (PD) patients before and after DBS.

Methods

Clinical assessment, resting-state functional MRI (rs-fMRI), and diffusion tensor imaging (DTI) were performed pre- and post-DBS in 15 PD patients, using a within-subject design. The rs-fMRI identified brain network topological metric and FC changes using graph-theory- and seed-based methods. White matter integrity was determined by DTI and tract-based spatial statistics.

Results

Unified Parkinson's Disease Rating Scale III (UPDRS- III) scores were significantly improved by 35.3% (p < 0.01) after DBS in PD patient

SUBMITTER: Huang LC 

PROVIDER: S-EPMC8673709 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature