UK experience of ofatumumab in recurrence of focal segmental glomerulosclerosis post-kidney transplant.

ABSTRACT:

Background

Steroid-resistant nephrotic syndrome (SRNS), commonly caused by focal segmental glomerulosclerosis (FSGS), is associated with progression to stage 5 chronic kidney disease, requirement for kidney replacement therapy and a risk of disease recurrence post-kidney transplantation. Ofatumumab (OFA) is a fully humanised monoclonal antibody to CD20, with similar mechanisms of action to rituximab (RTX).

Methods

We report a case series of seven UK patients (five paediatric, two adult), all of whom developed FSGS recurrence after kidney transplantation and received OFA as part of their therapeutic intervention. All also received concomitant plasmapheresis. The 2-year outcome of these seven patients is reported, describing clinical course, kidney function and proteinuria.

SUBMITTER: Reynolds BC 

PROVIDER: S-EPMC8674165 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature