Treatment-related calvarial lesions in pediatric brain tumor survivors.

ABSTRACT:

Background

Despite improved survival, many pediatric brain tumor survivors receiving radiation therapy (RT) experience late effects.

Procedure

To study calvarial lesions in this population, we retrospectively reviewed records of patients undergoing neurosurgical evaluation for calvarial bone lesions detected in posttreatment follow-up imaging at St. Jude Children's Research Hospital. Primary tumor diagnosis, treatment, imaging, surgical intervention, and histopathology from patients with radiographic evidence of lesions followed for ≥2 years post-RT were studied.

Results

For 17 patients with 18 index lesions, median time to lesion manifestation was 2.34 years. Medulloblastoma patients developed lesions at a shorter interval from RT than ependymoma patients (P = .05).

SUBMITTER: Wallace D 

PROVIDER: S-EPMC8674206 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature