Network-driven anomalous transport is a fundamental component of brain microvascular dysfunction.

ABSTRACT: Blood microcirculation supplies neurons with oxygen and nutrients, and contributes to clearing their neurotoxic waste, through a dense capillary network connected to larger tree-like vessels. This complex microvascular architecture results in highly heterogeneous blood flow and travel time distributions, whose origin and consequences on brain pathophysiology are poorly understood. Here, we analyze highly-resolved intracortical blood flow and transport simulations to establish the physical laws governing the macroscopic transport properties in the brain micro-circulation. We show that network-driven anomalous transport leads to the emergence of critical regions, whether hypoxic or with high concentrations of amyloid-β, a waste product centrally involved in Alzheimer's Disease. We develop a

SUBMITTER: Goirand F 

PROVIDER: S-EPMC8674232 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature